Accueil du site > Semiconducteurs, Matériaux et Capteurs > Equipe : Physique de l’Exciton, du Photon et du Spin > Thème : Biophotonique
The Bionanophotonics team was created in 2006 with the mission to conduct studies located at the interface between physics and life sciences. Our experimental biophysical approach to study complex biological systems is based on monitoring interaction of light with biological material through microscopic and spectroscopic techniques. The objectives defined within our collaborations with several biological teams and clinicians in the region are to better understand the molecular and cellular mechanisms involved in diseases such as cancer and neuropathy in order to propose new therapeutic approaches. The combination of advanced imaging techniques with molecular detection afforded by a novel generation of photonic biosensors is the strengths of our team addressing hereby the theme diagnosis and the follow-up therapy recognized of high importance by the international biomedical community.
The biophysical studies are performed in our laboratory comprising several original techniques :
Optical waveguide lightmode spectroscopy
Infrared spectroscopy in attenuated total reflexion mode
Inverted optical microscope (Nikon-TE2000) also working in epi-fluorescence and differential interference (Nomarski) contrast mode
Atomic Force microscopy (MFP3D-Asylum Research) mounted on an inverted optical microscope (Olympus) also working in epi-fluorescence and phase contrast
Multiphotonique microscope (mounted on a Zeiss microscope) working in two-photon excited fluorescence and second harmonic generation
The two main scientific themes we are developing are the photonics for bioimaging and photonic biosensing.
We develop and use spectroscopic and microscopic techniques to address the following collaborative subjects : 1. The action of anti-tumor drugs on cancer cells and on the organization of microtubules that are the target of chemo-therapy (CRLC Val d’Aurelle - INSERM U 896, UM1) 2. Early detection of oral cavity cancers based on the autofluorescence of malignant tissue (EA 4203, UM1) 3. Induction of neurogenesis in the treatment of peripheral sensory neuropathy (Institute of Neurosciences (...)
Next generation biosensors will require significant improvements in sensitivity, specificity and parallelism in order to meet the future needs of a variety of fields including in vitro medical diagnostics, pharmaceutical discovery and drug or pathogen detection. The interface between biological molecules and inorganic surfaces is a key issue for the development of devices based on biomolecular recognition. In particular, the efficiency of biosensing devices is directly determined by the (...)