Laboratoire Charles Coulomb UMR 5221 CNRS/UM2 (L2C)


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Thème : Biophotonique


The Bionanophotonics team was created in 2006 with the mission to conduct studies located at the interface between physics and life sciences. Our experimental biophysical approach to study complex biological systems is based on monitoring interaction of light with biological material through microscopic and spectroscopic techniques. The objectives defined within our collaborations with several biological teams and clinicians in the region are to better understand the molecular and cellular mechanisms involved in diseases such as cancer and neuropathy in order to propose new therapeutic approaches. The combination of advanced imaging techniques with molecular detection afforded by a novel generation of photonic biosensors is the strengths of our team addressing hereby the theme diagnosis and the follow-up therapy recognized of high importance by the international biomedical community.

The biophysical studies are performed in our laboratory comprising several original techniques :
- Optical waveguide lightmode spectroscopy
- Infrared spectroscopy in attenuated total reflexion mode
- Inverted optical microscope (Nikon-TE2000) also working in epi-fluorescence and differential interference (Nomarski) contrast mode
- Atomic Force microscopy (MFP3D-Asylum Research) mounted on an inverted optical microscope (Olympus) also working in epi-fluorescence and phase contrast
- Multiphotonique microscope (mounted on a Zeiss microscope) working in two-photon excited fluorescence and second harmonic generation

The two main scientific themes we are developing are the photonics for bioimaging and photonic biosensing.

Current researches

Photonics for bioimaging

We develop and use spectroscopic and microscopic techniques to address the following collaborative subjects :
1. The action of anti-tumor drugs on cancer cells and on the organization of (...)

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Photonic Biosensors

Next generation biosensors will require significant improvements in sensitivity, specificity and parallelism in order to meet the future needs of a variety of fields including in vitro medical (...)

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