Sommaire:

Synthetic DNA nanostructures can be designed to replicate the structure and function of biological molecules, as well as to create novel synthetic materials [1,2]. Particularly powerful and largely unexplored is the combination of selective Watson-Crick interactionsand robust hydrophobic forces,which can be realised in amphiphilic nanostructures where non-polar tags are arranged onto engineered DNA scaffolds.
I will discuss the use of amphiphilic DNA ligands/receptors to drive attractive interactions between lipid vesicles, sharing key features with adhering biological cells and displaying an intriguing response to external stimuli [3-8].In the second part I will introduce a range of amphiphilic DNA nanostructures that reliably self-assemble into 3D macromolecular crystals, [9], finally achieving a long-standing goal of structural DNA nanotechnology.


[1] L. Di Michele, E. Eiser, Phys. Chem. Chem. Phys. 15, 3115-3129 (2013)
[2] M. R. Jones, N. C. Seeman, C. A. Mirkin, Science 347, 1260901 (2015).
[3] L. Parolini, B.M. Mognetti, J. Kotar, E. Eiser, P. Cicuta*, L. Di Michele*, Nature Commun. 6, 5948 (2015).
[4] S.F. Shimobayashi, B.M. Mognetti, L. Parolini, D. Orsi, P. Cicuta, L. Di Michele, Phys. Chem. Chem. Phys. 17, 15615-15628 (2015).

[5] L. Parolini, J. Kotar, L. Di Michele*, BM Mognetti*, ACS nano10 (2), 2392-2398
[6] L. Di Michele, S.J. Bachmann, L. Parolini, B.M. Mognetti, J. Chem. Phys. 144 (16), 161104
[7] S.J. Bachmann, J.Kotar, L.Parolini, A.Šarić, P. Cicuta, L. Di Michele*, B.M. Mognetti*, Soft Matter 12 (37), 7804-7817
[8] O.A. Amjad, B.M. Mognetti, P. Cicuta*, and L. Di Michele*, under review
[9] R.A. Brady, N.J. Brooks, P.Cicuta*, L. Di Michele*, under review

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Pour plus d'informations, merci de contacter Truzzolillo D.