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(1) Presentation(s)

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Jeu. 20/04/2017 11:00 Grande Ourse, Bâtiment 13, Etage 1

Colloquium
WINGREEN Ned (Princeton University (USA))
Protein phase transitions in and out of cells

Sommaire:

Biologists have recently come to appreciate that eukaryotic cells are home to a multiplicity of non-membrane bound compartments, many of which form and dissolve as needed for the cell to function. These dynamical “liquid droplets” enable many central cellular functions – from ribosome assembly, to RNA regulation and storage, to signaling and metabolism. While it is clear that these compartments represent a type of separated phase, what controls their formation, how specific biological components are included or excluded, and how these structures influence physiological and biochemical processes remain largely mysterious. I will discuss recent experiments on phase separated droplets both in vitro and in vivo, and will present theoretical results that highlight a novel “magic number” effect relevant to the formation and control of two-component phase separated liquid droplets.


Pour plus d'informations, merci de contacter Berthier L.