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Résumé:

Our study concerns nano-objects consisting in an iron oxide core of 10(±2) nm or 20(±5) nm size, which exhibit superparamagnetic behavior, whose shell is constituted of dendrons carrying a dye. The characterization of the magnetic properties of these nano-objects together with their relaxivity into MRI will be presented in this poster. Their detection in an intraoperative context requires an instrument able to detect the extremely weak magnetic signature of the superparamagnetic nanoparticle in a noisy environment. A magnetic probe based on an AC magnetic field excitation of the nano-object coupled to an inductive gradiometer sensor has been designed to achieve this measurement. A conductive layer surrounding the probe is used to provide a shielding, thanks to the eddy current which will limit the leakage magnetic field outside of the probe. The principle of the probe and its ability to measure the magnetic signature of the magnetic nano-objects will be discussed.