Sommaire:

Nonequilibrium processes within living systems exact a metabolic price: the constant maintenance of fuel molecules and raw materials at sufficient concentrations to provide thermodynamic driving potentials for biological function. Whether/how the metabolic costs constrain biological processes and natural evolution remains elusive as the fitness of organisms is subject to many trade offs from bioenergetic costs to speed and accuracy of cellular processes. In this talk, I will present recent efforts in establishing a quantitative framework to study the role of metabolism in evolution of cellular processes and development of organisms.

In the first part, I will discuss the relation between the bioenergetics and evolution of cellular processes, and demonstrate the role of metabolic costs in shaping interaction affinities in gene regulatory (microRNA-mRNA) networks. In the second part, I will talk about how metabolism is linked to the body plan development of multicellular organisms in the light of our recent work on gut morphogenesis in planarians. Finally, I will present ideas to bridge theory of chemical reactions and soft-matter to elucidate spatial organization of metabolism in living systems allowing to drive biological processes across the entire organism.

Rejoindre Zoom Réunion
https://umontpellier-fr.zoom.us/j/98727884455?pwd=eHo1ck5xL2wzMnlEZG9qRFJmT2NiUT09

ID de réunion: 987 2788 4455
Code secret: 283617

Pour plus d'informations, merci de contacter Palmeri J.