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(1) Presentation(s)

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Jeu. 10/07/2014 15:00 BAT 11- RDC

Séminaire
SIMUNOVIC Mijo (Institut Curie - Paris)
Crossing the scales of protein-membrane interactions

(Matière Molle)


Sommaire:

The reshaping of cell membranes is deeply rooted in many biological processes. We combine theoretical modeling with experimental biophysics to study the driving force underlying the remodeling of biological membranes induced by BAR proteins. In particular, we employ a combination of coarse-grained simulations with field-theoretical and continuum methods to model the large-scale behavior of proteins on the membrane at molecular resolution. In addition, we use quantitative fluorescence and atomic force microscopy to elucidate the underlying mechanics and morphological changes of the membrane induced by BAR proteins at much larger time and length scales. We study how the molecular interactions couple to the long-wavelength membrane restructuring phenomena. Our research also sheds light on the complex and unknown role of the protein’s subdomains, namely the amphipathic helices, in interacting with the membrane and generating its curvature. Finally, it gives vital clues how protein self-assembly and crowding affect the mechanical properties of membranes to regulate their shape and dynamics in living cells.


Pour plus d'informations, merci de contacter Gross M.