Sommaire:

Integrin receptors mediate interaction between cells and extracellular matrix. These receptors do not possess any catalytic properties by themselves and must recruit additional signaling molecules upon activation to transmit signal to the cell. Using this property and starting from elementary biochemical modules governing integrin activation, we construct a reaction diffusion network based on receptor regulation. Including integrin receptor diffusion, our model generalizes previous abstract dynamical systems and aims at describing local production of a key phosphoinositide, i.e. PIP2(4,5) , which dictates the temporal and spatial activity of crucial processes such as integrin activation and clustering or actin polymerization. We describe local PIP2(4,5) production and integrin clustering as localized spike excitation waves which can be either static or dynamic. We discuss this model in the context of adhesive structures podosome type that are the hallmarks of invasive cells. In this context, we propose that static solutions correspond to cluster of podosomes and that dynamic solutions correspond to expanding rosette of podosomes. Our model allows connecting different types of integrin organization to their kinetic parameters.

Pour plus d'informations, merci de contacter Parmeggiani A.