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(1) Presentation(s)

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Ven. 30/01/2015 10:30 Salle RdC, Bâtiment 11, RdC

Séminaire
PINOT Mathieu (Institut Curie - Paris 75005)
Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins

(Matière Molle)


Sommaire:

Phospholipids (PLs) with polyunsaturated acyl chains are extremely abundant in a few
specialized cellular organelles such as synaptic vesicles and photoreceptor discs, but their
effect on membrane properties is poorly understood. Here, we found that polyunsaturated
PLs increased the ability of dynamin and endophilin to deform and vesiculate synthetic
membranes. When cells incorporated polyunsaturated fatty acids into PLs, the plasma
membrane became more amenable to deformation by a pulling force and the rate of
endocytosis was accelerated, in particular, under conditions in which cholesterol was
limiting. Molecular dynamics simulations and biochemical measurements indicated that
polyunsaturated PLs adapted their conformation to membrane curvature. Thus, by
reducing the energetic cost of membrane bending and fission, polyunsaturated PLs may
help to support rapid endocytosis.

Briefly, i will introduce before the role of a confinement on cytoskéleton self-organization (phD project).


Pour plus d'informations, merci de contacter Gross M.