Sommaire:

Fluorescent nanodiamonds (FNDs) represent a key component in recent development of ultra-high precision optical resolution techniques. FNDs can accommodate various color centers, including bright silicon-vacancy center (SiV) and nitrogen-vacancy (NV) center – extremely photostable crystal lattice defects emitting in near-infrared region. Electron transitions among NV quantum states can be influenced by very weak external electric or magnetic fields, which have been utilized for construction of various types of probes and nanosensors.
For application of FNDs in biological systems and for achieving high target selectivity, a precise control of particles’ bionanointerface is urgently needed. Different synthetic approaches towards bioapplicable FNDs will be presented. Creation of different antifouling polymeric coatings on FNDs, their physico-chemical comparison, bioorthogonal modification with various (bio)molecules using click chemistry, and imaging of cancer cells using these conjugates will be shown. Chemical aspects influencing interactions at FND surface will be discussed.

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