Biocompatible Periodic Mesoporous Ionosilica Nanoparticles with Ammonium Walls: Application to Drug Delivery Auteur(s): Bouchal Roza, Daurat Morgane, Gary-Bobo Magali, da Silva Afitz, Lesaffre Leila, Aggad Dina, Godefroy Anastasia, Dieudonne-George P., Charnay Clarence, Durand Jean-Olivier, Hesemann Peter (Article) Publié: Acs Appl. Mater. Interfaces, vol. 9 p.32018-32025 (2017) Ref HAL: hal-01625845_v1 DOI: 10.1021/acsami.7b07264 WoS: 000411771400085 Exporter : BibTex | endNote 6 Citations Résumé: Periodic mesoporous ionosilica nanoparticles with ammonium wallswere synthesized exclusively from a trisilylated ammonium precursor. The nanoparticlesdisplay a uniform particle size, together with a high specific surface area and anordered hexagonal pore architecture. Completely biocompatible in vitro and in vivo,the nanoparticles are efficiently endocytosed by RAW 264.7 macrophages and used ascarrier vehicles for anionic drugs. Diclofenac-loaded ionosilica nanoparticles are veryefficient in inhibiting lipopolysaccharides-induced inflammation. |