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We investigated bone regeneration in vitro and in vivo, using porous silicon (pSi) microparticles coupled with nacre proteins. We prepared a composite powder formed by pSi particles loaded with phosphate, and nacre proteins carrying calcium. For in vitro experiments, we used primary culture of human Dental Pulp Stem Cells. Results showed efficiency for both cell adhesion, cell differentiation and CaPO4 formation. But the most interesting results were that this composite was highly efficient to regenerate bone in vivo, even without any additional stem cells grafting.