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Mer. 10/04/2024 09:45 Bâtiment 20, Amphi Colloquium
BAIGL Damien (PASTEUR, Ecole Normale Superieure, PSL University, Sorbonne Université, CNRS)
Synthetic self-assembly with life-like properties
Sommaire:
Self-assembly is both an advantageously spontaneous process to organize molecular or colloidal entities into functional superstructures and a key-feature of how life builds its components. However, compared to their living counterparts, synthetic materials made by self-assembly usually lack some of the interesting properties of living systems such as multicomponent character or capability to adapt, transform and evolve. In this presentation, I will describe different systems where life-like properties can emerge from self-assembled synthetic materials. First, I will show that user-defined and elaborate nanostructures (e.g., DNA origamis, nanogrids, SST assemblies) can be obtained by the isothermal self-assembly of hundreds of different DNA bricks and proteins with a unique capability to optimize, adapt, evolve and even completely transform their morphology, either spontaneously or under command [1-2]. I will also present a new DNA self-assembly principle that does not rely on base-pairing principles, showing in particular that photosensitive DNA intercalating molecules can co-assemble with DNA bases to form new extended supramolecular materials with intriguing dynamic properties. I will describe in particular the formation of photoswitchable 3D crystals with unique photoreversible growth and light-gated fluorescence [3]. Finally, I will present different colloidal self-assembly processes at air-water or liquid-liquid interfaces and explore how dynamic properties can emerge from such systems. Starting from the familiar situation of drying drop containing a colloidal suspensions, we have been interested in controlling/cancelling the so-called “coffee-ring effect” [4-7] or turning it into a low-cost yet powerful medical diagnostic tool [8]. In such systems, however, particles adsorb at the interface to form amorphous structures. This led us to invent a simple method in which bulk particles adsorb at the water-interface and directly crystallize there. Based on the use of ultralow amounts of surfactant, 2D colloidal crystals spontaneously form without any other applied force than their own weight [9]. This method allows us to crystallize a broad variety of nanometric and micrometric particles, including those made of polymers, metals or inorganic materials, and tune the characteristics of the colloidal crystals [LF] that can be further deposited on solid substrates [11]. These colloidal crystals display intense structural colors as well as, under some conditions, some remarkable dynamic properties at the air/water interface. For instance, using light, we can reversibly melt/crystallize these colloidal assemblies on command, evidencing other life-like properties, such as dissipative character or living crystallization [12-CR].
[1] Rossi-Gendron et al., Nat. Nanotechnol. 2023, 18, CR11–CR18
[2] Nakazawa et al., Angew. Chem. Int. Ed. 2021, 60, 15214 –15219
[3] Zhou et al., J. Am. Chem. Soc. 2019, 141, 9321–9329
[4] Anyfantakis et al., Angew. Chem. Int. Ed. 2014, 53, 14077–14081
[5] Varanakkottu et al., Nano Lett. 2016, 16, 644–650
[6] Poulichet et al., J. Colloid. Interf. Sci. 2020, 573, 370-375
[7] Galy et al., ACS Appl. Mater. Interfaces 2022, 14, 3374–3384
[8] Devineau et al., J. Am. Chem. Soc. 2016, CR8, 11623–11632
[9] Anyfantakis, Langmuir 2018, 34, 15526−15536
[LF] Vialetto et al., Nanoscale 2020, 12, 6279-6284
[11] Vialetto et al., Adv. Sci. 2024, 11, 2307893
[12] Vialetto et al. Angew. Chem. Int. Ed. 2019, 58, 9145-9149
[CR] Vialetto et al., J. Am. Chem. Soc. 2021, 143, 11535−11543 Pour plus d'informations, merci de contacter Poy G.
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