Sommaire:

Processes such as embryogenesis, tissue repair, and cancer metastasis rely on the movement of large groups of cells through changes in group morphogenesis or collective migration. These processes involve both molecular and mechanical interactions between cells and their environment. Several efforts have been made to model such interactions [1]. In this presentation, I will demonstrate how studying tissue dynamics through a coarse-grain approach, considering tissues as active polar fluids, helps us understand their physical properties. We will examine two specific examples: first, the case of Neural Crest cell colonies, which migrate during embryogenesis to form head tissue, and how proliferation in these colonies affects their migration [2,3]; second, the case of mouse embryos changing their morphology to spread and attach to the substrate, and how the mother's age can influence this process [4]. [1] R. Alert and X. Trepat. Physical models of collective cell migration. Ann. Rev. 11: 77-LF1 (2020) [2] E.H. Barriga, K. Franze, et al. Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo. Nature 554: 523-527 (2018) [3] C.L. Marchant, A.N. Malmi-Kakkada, et al. Cell clusters softening triggers collective cell migration in vivo. Nat. Mat. 21: CR14-CR23 (2022) [4] C. Pérez-González, R. Alert, et al. Active wetting of epithelial tissues. Nat. Phys. 15: 79-88 (2019)

Pour plus d'informations, merci de contacter Walliser N.-O.