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Mechanical instabilities of aorta drive blood stem cell production: a live study 
Auteur(s): Poullet Nausicaa, Golushko I., Lorman V., Travnickova Jana, Chalin Dmitryi, Rochal Sergei, Parmeggiani A., Kissa Karima
(Document sans référence bibliographique) Texte intégral en Openaccess : 
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DOI: 10.1101/509190
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Résumé: During embryogenesis of all vertebrates, haematopoietic stem/progenitor cells 16 (HSPCs) extrude from the aorta by a complex process named Endothelial-to-17 Haematopoietic Transition (EHT). HSPCs will then colonize haematopoietic organs 18 allowing haematopoiesis throughout adult life. The mechanism underlying EHT 19 including the role of each aortic endothelial cell within the global aorta dynamics 20 remains unknown. In the present study, we show for the first time that EHT involves the 21 remodelling of individual cells within a collective migration of endothelial cells which is 22 tightly orchestrated, resulting in HSPCs extrusion in the sub-aortic space without 23 compromising aorta integrity. By performing a cross-disciplinary study which combines 24 high resolution 4D imaging and theoretical analysis based on the concepts of classical 25 mechanics, we propose that this complex developmental process is dependent on 26 mechanical instabilities of the aorta preparing and facilitating the extrusion of HSPCs. 27 28 29 We dedicate this work to the memory of our friend and colleague, V. Lorman. 30 31 All rights reserved. No reuse allowed without permission. (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.
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NUMEV : Solutions Numériques, Matérielles et Modélisation pour l’Environnement et le Vivant
Auteur(s): Parmeggiani A. , Torres Lionel
(Autres publications)
, 2018
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Résumé: Description du LabEx NUMEV dans le dossier Agropolis International sur la Modélisation en Occitanie
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Vladimir Lorman and the Physics of Unconventional Systems
Auteur(s): Parmeggiani A.
Conférence invité: Biophysics and Beyond: the Physics of Unconventional Systems - In honour of Prof. Vladimir Lorman (Montpellier, FR, 2018-04-03)
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Modelling Spatio-temporal Dynamic of Ribosome During Translation
Auteur(s): Chevalier C., Walter J.-C., Palmeri J., Parmeggiani A., Geniet F., Dorignac J., Walliser N.-O., Rivals Eric, Paulet Damien, David Alexandre
(Affiches/Poster)
7ème Journées Scientifiques du LabEx NUMEV (Montpellier, FR), 2018-11-27Texte intégral en Openaccess :
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Résumé: Translation of messenger RNA (mRNA) leads to the production of proteins and is the last step of gene expression in cells. The dysregulation of translation can lead to all illnesses linked to the dysregulation of protein production, like cancer and neurodegenerative diseases.About ten years ago, a ribosomal density mapping strategy (Ribo-seq) was developed. The time is therefore ripe to apply theoretical physicsmethods to study translation. We model the movement of ribosomes on mRNA using the Totally Asymmetric Simple Exclusion Process (TASEP) which is an out of equilibrium one dimensional directed transport model. With Monte Carlo simulations and a mean field approach, we propose a way to calculate the speed of ribosomes from experimental data. Moreover, we provide preliminary results concerning the correlation between the speed of ribosomes and the occurrence rate of codons (RSCU).
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Laboratory of Excellence NUMEV: Digital and Hardware Solutions, Environmental and Organic Life Modeling
Auteur(s): Parmeggiani A.
Conférence invité: UC-Davis at MUSE-Unversity in Montpellier (Montpellier, FR, 2018-09-07)
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Résumé: NUMEV activities presentation during the visit of UC-Davis University in MUSE Montpellier
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