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(11) Production(s) de NERI I.

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Towards modelling motor protein driven cytoskeltal transport

Auteur(s): Kern N. (Corresp.) , Parmeggiani A., Raguin A., Neri I.

Conference: Mechanisms driving the organization of intra-cellular organelles (Zaragoza, ES, 2012-06-18)

Résumé:

One important role which the cytoskeleton plays in cells is to provide a network of filaments along which molecular motors can procede. This provides an essential mechanism by which a cell can establish transport of cargos over distances of the order of the cell size. The details of how such motors achieve procession along the biofilaments constituting the cytoskeleton are very complex indeed, but much of their behaviour (including collective aspects of the transport) can be described in terms of well-established models, such as the Totally Asymmetric Transport Process (TASEP) or similar. These are well-studied on single filaments. Recent work has allowed us to establish a framework to transpose this understanding to an overall network of interconnected filaments, mimicking the cytoskeleton. We discuss how new aspects of heterogeneity arise on the network scale, and we aOne important role which the cytoskeleton plays in cells is to provide a network of filaments along which molecular motors can procede. This provides an essential mechanism by which a cell can establish transport of cargos over distances of the order of the cell size. The details of how such motors achieve procession along the biofilaments constituting the cytoskeleton are very complex indeed, but much of their behaviour (including collective aspects of the transport) can be described in terms of well-established models, such as the Totally Asymmetric Transport Process (TASEP) or similar. These are well-studied on single filaments. Recent work has allowed us to establish a framework to transpose this understanding to an overall network of interconnected filaments, mimicking the cytoskeleton. We discuss how new aspects of heterogeneity arise on the network scale, and we argue that they are generic to many types of transport on networks. We also present very recent ideas for incorporating more complex features aimed at applying the approach to cytoskeletal transport in particular. rgue that they are generic to many types of transport on networks. We also present very recent ideas for incorporating more complex features aimed at applying the approach to cytoskeletal transport in particular.